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multiple comparison chi-square test with bonferroni correction  (CH Instruments)

 
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    CH Instruments multiple comparison chi-square test with bonferroni correction
    Multiple Comparison Chi Square Test With Bonferroni Correction, supplied by CH Instruments, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/product/chi-squared+comparison/pm40344083-174-14-11?v=CH+Instruments
    Average 90 stars, based on 1 article reviews
    multiple comparison chi-square test with bonferroni correction - by Bioz Stars, 2026-07
    90/100 stars

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    Summary of changes in chemokine and cytokine production by PBMC from Leprosy Patients and Household Contacts upon in vitro culture. The levels of chemokines (CXCL8, CCL2, CXCL9, CCL5, CXCL10) and cytokines (IL-6, TNF, IFN-γ, IL-17, IL-4, IL-10 and IL-2) were measured in the supernatant from in vitro cultured PBMC from leprosy patients (L, n=79), household contacts (HHC, n=91) and endemic controls (EC, n=87). Data were obtained in the absence of exogenous stimuli (Unstimulated Culture) and the presence of M. leprae antigen stimuli (M. leprae-stimulated Culture). Cytometric Beads Array (CBA) performed quantitative analysis of chemokines and cytokines according to manufacturer instructions. (A) Major changes observed in soluble mediators amongst groups were summarized considering the fold changes in concentrations detected in PBMC culture supernatants from HHC and L according to EC (Fold Change in concentration = HHC/EC or <t>L/EC).</t> <t>Log10</t> of Fold Change values (magnitude) was combined with the -Log10 p values (significance) obtained by Dunn’s post-test for multiple comparisons. (B) Differences in chemokines and cytokines signatures were assessed according to EC <t>(Delta</t> in % = %HHC – %EC). Log10 of Delta values (magnitude) was combined with the -Log10 p values (significance) obtained by Chi-square comparisons. (C) Differences in chemokines and cytokines network correlations were assessed according to EC (Delta in correlation numbers = HHC – EC or L – EC). Delta values (magnitude) were combined with the % of correlations from EC (threshold = decrease or increase > 33%). In all cases, significant decrease ( ), increase ( ), or non-significant changes ( ) are highlighted on each chart distribution.
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    Summary of changes in chemokine and cytokine production by PBMC from Leprosy Patients and Household Contacts upon in vitro culture. The levels of chemokines (CXCL8, CCL2, CXCL9, CCL5, CXCL10) and cytokines (IL-6, TNF, IFN-γ, IL-17, IL-4, IL-10 and IL-2) were measured in the supernatant from in vitro cultured PBMC from leprosy patients (L, n=79), household contacts (HHC, n=91) and endemic controls (EC, n=87). Data were obtained in the absence of exogenous stimuli (Unstimulated Culture) and the presence of M. leprae antigen stimuli (M. leprae-stimulated Culture). Cytometric Beads Array (CBA) performed quantitative analysis of chemokines and cytokines according to manufacturer instructions. (A) Major changes observed in soluble mediators amongst groups were summarized considering the fold changes in concentrations detected in PBMC culture supernatants from HHC and L according to EC (Fold Change in concentration = HHC/EC or L/EC). Log10 of Fold Change values (magnitude) was combined with the -Log10 p values (significance) obtained by Dunn’s post-test for multiple comparisons. (B) Differences in chemokines and cytokines signatures were assessed according to EC (Delta in % = %HHC – %EC). Log10 of Delta values (magnitude) was combined with the -Log10 p values (significance) obtained by Chi-square comparisons. (C) Differences in chemokines and cytokines network correlations were assessed according to EC (Delta in correlation numbers = HHC – EC or L – EC). Delta values (magnitude) were combined with the % of correlations from EC (threshold = decrease or increase > 33%). In all cases, significant decrease ( ), increase ( ), or non-significant changes ( ) are highlighted on each chart distribution.

    Journal: Frontiers in Immunology

    Article Title: The landscape of chemokine and cytokine is associated with the distinct clinical status of leprosy patients and their respective household contacts

    doi: 10.3389/fimmu.2024.1476450

    Figure Lengend Snippet: Summary of changes in chemokine and cytokine production by PBMC from Leprosy Patients and Household Contacts upon in vitro culture. The levels of chemokines (CXCL8, CCL2, CXCL9, CCL5, CXCL10) and cytokines (IL-6, TNF, IFN-γ, IL-17, IL-4, IL-10 and IL-2) were measured in the supernatant from in vitro cultured PBMC from leprosy patients (L, n=79), household contacts (HHC, n=91) and endemic controls (EC, n=87). Data were obtained in the absence of exogenous stimuli (Unstimulated Culture) and the presence of M. leprae antigen stimuli (M. leprae-stimulated Culture). Cytometric Beads Array (CBA) performed quantitative analysis of chemokines and cytokines according to manufacturer instructions. (A) Major changes observed in soluble mediators amongst groups were summarized considering the fold changes in concentrations detected in PBMC culture supernatants from HHC and L according to EC (Fold Change in concentration = HHC/EC or L/EC). Log10 of Fold Change values (magnitude) was combined with the -Log10 p values (significance) obtained by Dunn’s post-test for multiple comparisons. (B) Differences in chemokines and cytokines signatures were assessed according to EC (Delta in % = %HHC – %EC). Log10 of Delta values (magnitude) was combined with the -Log10 p values (significance) obtained by Chi-square comparisons. (C) Differences in chemokines and cytokines network correlations were assessed according to EC (Delta in correlation numbers = HHC – EC or L – EC). Delta values (magnitude) were combined with the % of correlations from EC (threshold = decrease or increase > 33%). In all cases, significant decrease ( ), increase ( ), or non-significant changes ( ) are highlighted on each chart distribution.

    Article Snippet: The Log10 of Delta values (magnitude) was combined with the -Log10 p values (significance) obtained by Chi-square comparisons.

    Techniques: In Vitro, Cell Culture, Concentration Assay

    Summary of changes in chemokine and cytokine production by PBMC from Leprosy Patients and Household Contacts according to operational classification upon in vitro culture. The levels of chemokines (CXCL8, CCL2, CXCL9, CCL5, CXCL10) and cytokines (IL-6, TNF, IFN-γ, IL-17, IL-4, IL-10 and IL-2) were measured in the supernatant from in vitro cultured PBMC from leprosy patients [L(PB), n=23 and L(MB), n= 56] and household contacts [HHC(PB), n=20 and HHC(MB), n= 68] subgroups. Data were obtained in the absence of exogenous stimuli (Unstimulated Culture) and the presence of M. leprae antigen stimuli (M. leprae-stimulated Culture). Quantitative analysis of chemokines and cytokines was carried out by Cytometric Beads Array (CBA) according to manufacturer instructions. (A) Major changes observed in soluble mediators amongst subgroups according to operational classification were summarized considering the fold changes in concentrations detected in PBMC culture supernatants from MB according to PB subjects [Fold Change in concentration HHC(MB)/HHC(PB) or L(MB)/L(PB)]. Log10 of Fold Change values (magnitude) was combined with the -Log10 p values (significance) obtained by Dunn’s post-test for multiple comparisons. (B) Differences in chemokines and cytokines signatures were assessed according to PB subjects [Delta in % = %HHC(MB) – %HHC(PB) or %L(MB) – %L(PB)]. Log10 of Delta values (magnitude) was combined with the -Log10 p values (significance) obtained by Chi-square comparisons. (C) Differences in chemokines and cytokines network correlations were assessed according to PB subjects [Delta in correlation numbers = HHC(MB) – HHC(PB) or L(MB) – L(PB)]. Delta values (magnitude) were combined with the % of correlations from EC (threshold = decrease or increase > 33%). In all cases, significant decrease ( ), increase ( ), or non-significant changes ( ) are highlighted on each chart distribution.

    Journal: Frontiers in Immunology

    Article Title: The landscape of chemokine and cytokine is associated with the distinct clinical status of leprosy patients and their respective household contacts

    doi: 10.3389/fimmu.2024.1476450

    Figure Lengend Snippet: Summary of changes in chemokine and cytokine production by PBMC from Leprosy Patients and Household Contacts according to operational classification upon in vitro culture. The levels of chemokines (CXCL8, CCL2, CXCL9, CCL5, CXCL10) and cytokines (IL-6, TNF, IFN-γ, IL-17, IL-4, IL-10 and IL-2) were measured in the supernatant from in vitro cultured PBMC from leprosy patients [L(PB), n=23 and L(MB), n= 56] and household contacts [HHC(PB), n=20 and HHC(MB), n= 68] subgroups. Data were obtained in the absence of exogenous stimuli (Unstimulated Culture) and the presence of M. leprae antigen stimuli (M. leprae-stimulated Culture). Quantitative analysis of chemokines and cytokines was carried out by Cytometric Beads Array (CBA) according to manufacturer instructions. (A) Major changes observed in soluble mediators amongst subgroups according to operational classification were summarized considering the fold changes in concentrations detected in PBMC culture supernatants from MB according to PB subjects [Fold Change in concentration HHC(MB)/HHC(PB) or L(MB)/L(PB)]. Log10 of Fold Change values (magnitude) was combined with the -Log10 p values (significance) obtained by Dunn’s post-test for multiple comparisons. (B) Differences in chemokines and cytokines signatures were assessed according to PB subjects [Delta in % = %HHC(MB) – %HHC(PB) or %L(MB) – %L(PB)]. Log10 of Delta values (magnitude) was combined with the -Log10 p values (significance) obtained by Chi-square comparisons. (C) Differences in chemokines and cytokines network correlations were assessed according to PB subjects [Delta in correlation numbers = HHC(MB) – HHC(PB) or L(MB) – L(PB)]. Delta values (magnitude) were combined with the % of correlations from EC (threshold = decrease or increase > 33%). In all cases, significant decrease ( ), increase ( ), or non-significant changes ( ) are highlighted on each chart distribution.

    Article Snippet: The Log10 of Delta values (magnitude) was combined with the -Log10 p values (significance) obtained by Chi-square comparisons.

    Techniques: In Vitro, Cell Culture, Concentration Assay